Convenient one-step synthesis of alkoxy substituted pyrazine derivatives

Abstract

We report a one-step method for the synthesis of alkoxy substituted pyrazine derivatives. The process makes use of an improved acid-mediated coupling reaction to afford the products in good yields (70–90%). This method expands the scope to alkoxy substituted pyrazine structures that are poorly represented in literature.

Keywords

• Pyrazine
• Favipiravir
• Thionyl chloride
• Nucleophilic aromatic substitution