Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer

Dingxiao Zhang; Daechan Park; Yi Zhong; Yue Lu; Kiera Rycaj; Shuai Gong; Xin Chen; Xin Liu; Hsueh-Ping Chao; Pamela Whitney; Tammy Calhoun-Davis; Yoko Takata; Jianjun Shen; Vishwanath R. Iyer; Dean G. Tang

doi:10.1038/ncomms10798

Nature Communications (Feb 2016)

Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer

Dingxiao Zhang,
Daechan Park,
Yi Zhong,
Yue Lu,
Kiera Rycaj,
Shuai Gong,
Xin Chen,
Xin Liu,
Hsueh-Ping Chao,
Pamela Whitney,
Tammy Calhoun-Davis,
Yoko Takata,
Jianjun Shen,
Vishwanath R. Iyer,
Dean G. Tang

Affiliations

Dingxiao Zhang: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Daechan Park: Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, University of Texas at Austin
Yi Zhong: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Yue Lu: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Kiera Rycaj: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Shuai Gong: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Xin Chen: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Xin Liu: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Hsueh-Ping Chao: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Pamela Whitney: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Tammy Calhoun-Davis: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Yoko Takata: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Jianjun Shen: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Vishwanath R. Iyer: Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, University of Texas at Austin
Dean G. Tang: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/ncomms10798
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

Read online

Gene-expression profiles can be used to predict the prognosis of cancer patients. Here, the authors describe gene expression profiles of human prostate epithelial lineages and show that basal cells have intrinsic stem and neurogenic properties, and molecularly resemble aggressive prostate cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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