Nature Communications (Apr 2022)
Deficiency in coatomer complex I causes aberrant activation of STING signalling
- Annemarie Steiner,
- Katja Hrovat-Schaale,
- Ignazia Prigione,
- Chien-Hsiung Yu,
- Pawat Laohamonthonkul,
- Cassandra R. Harapas,
- Ronnie Ren Jie Low,
- Dominic De Nardo,
- Laura F. Dagley,
- Michael J. Mlodzianoski,
- Kelly L. Rogers,
- Thomas Zillinger,
- Gunther Hartmann,
- Michael P. Gantier,
- Marco Gattorno,
- Matthias Geyer,
- Stefano Volpi,
- Sophia Davidson,
- Seth L. Masters
Affiliations
- Annemarie Steiner
- Inflammation Division, The Walter and Eliza Hall Institute of Medical Research
- Katja Hrovat-Schaale
- Inflammation Division, The Walter and Eliza Hall Institute of Medical Research
- Ignazia Prigione
- Centre for Autoinflammatory Diseases and Primary Immunodeficiencies, IRCCS Istituto Giannina Gaslini
- Chien-Hsiung Yu
- Inflammation Division, The Walter and Eliza Hall Institute of Medical Research
- Pawat Laohamonthonkul
- Inflammation Division, The Walter and Eliza Hall Institute of Medical Research
- Cassandra R. Harapas
- Inflammation Division, The Walter and Eliza Hall Institute of Medical Research
- Ronnie Ren Jie Low
- Department of Medical Biology, University of Melbourne
- Dominic De Nardo
- Inflammation Division, The Walter and Eliza Hall Institute of Medical Research
- Laura F. Dagley
- Department of Medical Biology, University of Melbourne
- Michael J. Mlodzianoski
- Center for Dynamic Imaging, The Walter and Eliza Hall Institute of Medical Research
- Kelly L. Rogers
- Center for Dynamic Imaging, The Walter and Eliza Hall Institute of Medical Research
- Thomas Zillinger
- Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn
- Gunther Hartmann
- Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn
- Michael P. Gantier
- Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research
- Marco Gattorno
- Centre for Autoinflammatory Diseases and Primary Immunodeficiencies, IRCCS Istituto Giannina Gaslini
- Matthias Geyer
- Institute of Structural Biology, University Hospital Bonn
- Stefano Volpi
- Centre for Autoinflammatory Diseases and Primary Immunodeficiencies, IRCCS Istituto Giannina Gaslini
- Sophia Davidson
- Inflammation Division, The Walter and Eliza Hall Institute of Medical Research
- Seth L. Masters
- Inflammation Division, The Walter and Eliza Hall Institute of Medical Research
- DOI
- https://doi.org/10.1038/s41467-022-29946-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Mutations in the coatomer complex I can result in endoplasmic reticulum stress and inflammatory consequences. Here authors define aberrant activation of the STING immunosensing pathway in a disturbed coatmer complex context and the therapeutic modulation of this axis to counter the associated immunopathology.
