Dual drugs release from nanoporously bioactive coating on polyetheretherketone for enhancement of antibacterial activity, rBMSCs responses and osseointegration

Fei Zou; Feizhou Lv; Xiaosheng Ma; Xinlei Xia; Liang Cai; Shiqi Mei; Jie Wei; Yunfei Niu; Jianyuan Jiang

Materials & Design (Mar 2020)

Dual drugs release from nanoporously bioactive coating on polyetheretherketone for enhancement of antibacterial activity, rBMSCs responses and osseointegration

Fei Zou,
Feizhou Lv,
Xiaosheng Ma,
Xinlei Xia,
Liang Cai,
Shiqi Mei,
Jie Wei,
Yunfei Niu,
Jianyuan Jiang

Affiliations

Fei Zou: Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai 200040, China
Feizhou Lv: Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai 200040, China
Xiaosheng Ma: Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai 200040, China
Xinlei Xia: Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai 200040, China
Liang Cai: Key Laboratory for Ultrafine Materials, Ministry of Education, East China University of Science and Technology, Shanghai 200237, China
Shiqi Mei: Key Laboratory for Ultrafine Materials, Ministry of Education, East China University of Science and Technology, Shanghai 200237, China
Jie Wei: Key Laboratory for Ultrafine Materials, Ministry of Education, East China University of Science and Technology, Shanghai 200237, China
Yunfei Niu: Department of Orthopaedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China; Corresponding authors.
Jianyuan Jiang: Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai 200040, China; Corresponding authors.

Journal volume & issue: Vol. 188

Abstract

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A bioactive coating of nanoporous magnesium calcium silicate (n-MCS) on polyetheretherketone (ncPK) surface was prepared, and dual drugs of genistein (GS) and curcumin (CR) were co-loaded into coating of ncPK (dncPK). The results revealed that compared with polyetheretherketone (PEEK), surface roughness, wettability and apatite mineralization ability of both ncPK and dncPK obviously improved, which promoted the rat bone mesenchymal stem cells (rBMSCs) adhesion. In addition, compared with ncPK and PEEK, dncPK significantly promoted the proliferation and differentiation of rBMSCs. Compared with ncPK and PEEK, dncPK displayed superior antibacterial activity to Escherichia coli and Staphylococcus aureus. The Micro-CT, histological and push-out load evaluations revealed that compared with ncPK and PEEK, dncPK remarkably accelerated osteogenesis and osseointegration in vivo. The results demonstrated that dual drugs-loaded dncPK exhibited good antibacterial activity and osteogenic activity, and significantly enhanced osteogenesis and osseointegration, which could be an alternative candidate as an implant in orthopedic and dental applications. Keywords: Polyetheretherketone, Nanoporous coating, Dual drugs, Antibacterial activity, Osseointegration

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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