Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis

Revati Darp; Marc A. Vittoria; Neil J. Ganem; Craig J. Ceol

doi:10.1038/s41467-022-31899-9

Nature Communications (Jul 2022)

Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis

Revati Darp,
Marc A. Vittoria,
Neil J. Ganem,
Craig J. Ceol

Affiliations

Revati Darp: University of Massachusetts Chan Medical School, Program in Molecular Medicine
Marc A. Vittoria: Departments of Pharmacology and Experimental Therapeutics and Medicine, Division of Hematology and Oncology, Boston University School of Medicine
Neil J. Ganem: Departments of Pharmacology and Experimental Therapeutics and Medicine, Division of Hematology and Oncology, Boston University School of Medicine
Craig J. Ceol: University of Massachusetts Chan Medical School, Program in Molecular Medicine

DOI: https://doi.org/10.1038/s41467-022-31899-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Whole-genome doubling (WGD) commonly occurs in many solid tumors. Here the authors use a zebrafish model of melanoma and in vitro models to show that BRAFV600E induces WGD via inhibition of RhoA and cytokinesis failure.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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