Nature Communications (Feb 2022)

Heterotypic interactions drive antibody synergy against a malaria vaccine candidate

  • Robert J. Ragotte,
  • David Pulido,
  • Amelia M. Lias,
  • Doris Quinkert,
  • Daniel G. W. Alanine,
  • Abhishek Jamwal,
  • Hannah Davies,
  • Adéla Nacer,
  • Edward D. Lowe,
  • Geoffrey W. Grime,
  • Joseph J. Illingworth,
  • Robert F. Donat,
  • Elspeth F. Garman,
  • Paul W. Bowyer,
  • Matthew K. Higgins,
  • Simon J. Draper

DOI
https://doi.org/10.1038/s41467-022-28601-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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Antibodies can have synergistic effects, but mechanisms are not well understood. Here, Ragotte et al. identify three antibodies that bind neighbouring epitopes on CyRPA, a malaria vaccine candidate, and show that lateral interactions between the antibodies slow dissociation and inhibit parasite growth synergistically.