Context-dependent enhancer function revealed by targeted inter-TAD relocation

Christopher Chase Bolt; Lucille Lopez-Delisle; Aurélie Hintermann; Bénédicte Mascrez; Antonella Rauseo; Guillaume Andrey; Denis Duboule

doi:10.1038/s41467-022-31241-3

Nature Communications (Jun 2022)

Context-dependent enhancer function revealed by targeted inter-TAD relocation

Christopher Chase Bolt,
Lucille Lopez-Delisle,
Aurélie Hintermann,
Bénédicte Mascrez,
Antonella Rauseo,
Guillaume Andrey,
Denis Duboule

Affiliations

Christopher Chase Bolt: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)
Lucille Lopez-Delisle: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)
Aurélie Hintermann: Department of Genetics and Evolution, Faculty of Sciences, University of Geneva
Bénédicte Mascrez: Department of Genetics and Evolution, Faculty of Sciences, University of Geneva
Antonella Rauseo: Department of Medical Genetics, Faculty of Medicine, University of Geneva
Guillaume Andrey: Department of Medical Genetics, Faculty of Medicine, University of Geneva
Denis Duboule: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)

DOI: https://doi.org/10.1038/s41467-022-31241-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Here the authors show that a strong enhancer sequence can be controlled by the chromatin environment provided by a topologically associated domain (TAD) located nearby. An enhancer relocated by homologous recombination takes all the hallmarks of its new neighboring enhancers located in the recipient TAD.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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