Nature Communications (May 2016)
Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
- Xiaoming Wang,
- Alexandra L. Bey,
- Brittany M. Katz,
- Alexandra Badea,
- Namsoo Kim,
- Lisa K. David,
- Lara J. Duffney,
- Sunil Kumar,
- Stephen D. Mague,
- Samuel W. Hulbert,
- Nisha Dutta,
- Volodya Hayrapetyan,
- Chunxiu Yu,
- Erin Gaidis,
- Shengli Zhao,
- Jin-Dong Ding,
- Qiong Xu,
- Leeyup Chung,
- Ramona M. Rodriguiz,
- Fan Wang,
- Richard J. Weinberg,
- William C. Wetsel,
- Kafui Dzirasa,
- Henry Yin,
- Yong-hui Jiang
Affiliations
- Xiaoming Wang
- Department of Pediatrics, Duke University
- Alexandra L. Bey
- Department of Neurobiology, Duke University
- Brittany M. Katz
- Department of Psychiatry and Behavioral Sciences, Duke University
- Alexandra Badea
- Department of Radiology, Duke University
- Namsoo Kim
- Department of Psychology and Neuroscience, Duke University
- Lisa K. David
- Department of Psychology and Neuroscience, Duke University
- Lara J. Duffney
- Department of Pediatrics, Duke University
- Sunil Kumar
- Department of Psychiatry and Behavioral Sciences, Duke University
- Stephen D. Mague
- Department of Psychology and Neuroscience, Duke University
- Samuel W. Hulbert
- Department of Neurobiology, Duke University
- Nisha Dutta
- Department of Cell Biology, Duke University
- Volodya Hayrapetyan
- Department of Psychology and Neuroscience, Duke University
- Chunxiu Yu
- Department of Psychology and Neuroscience, Duke University
- Erin Gaidis
- Department of Psychology and Neuroscience, Duke University
- Shengli Zhao
- Department of Neurobiology, Duke University
- Jin-Dong Ding
- Department of Ophthalmology, Duke University
- Qiong Xu
- Department of Pediatrics, Duke University
- Leeyup Chung
- Department of Pediatrics, Duke University
- Ramona M. Rodriguiz
- Department of Psychiatry and Behavioral Sciences, Duke University
- Fan Wang
- Department of Neurobiology, Duke University
- Richard J. Weinberg
- Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill
- William C. Wetsel
- Department of Neurobiology, Duke University
- Kafui Dzirasa
- Department of Psychiatry and Behavioral Sciences, Duke University
- Henry Yin
- Department of Psychology and Neuroscience, Duke University
- Yong-hui Jiang
- Department of Pediatrics, Duke University
- DOI
- https://doi.org/10.1038/ncomms11459
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 18
Abstract
SHANK3 mutations have been linked to autism spectrum disorders, although the underlying mechanisms remain unclear. Here, the authors generate a complete knockout Shank3 mouse model, identifying ASD-like behaviours associated with impaired mGluR5-Homer scaffolding and abnormal brain connectivity.
