Oxidative stress parameters in patients with Meniere disease

Abstract

Introduction: The role of oxidative stres in patients with Meniere disease (MD), is still unresearched. The aim: The aim was to compare serum levels of total and direct bilirubin, albumins, uric acid and creatinine as antioxidative status parameters in patients with MD with healthy controls, and patients with multiple sclerosis (MS). Methods: We divided patients in three groups - 85 MD patients, 75 healthy controls (HC) and 72 MS patients. Patients with MD were divided into groups according to sex, age at the time of the disease onset, and number of attacs per year. Severity of clinical presentation during the attack was assessed by Vertigo Symptom Scale. Results: The serum levels of all parameters were significantly lower in MD and MS group compared to the healthy control group (p<0.05). Regarding severity of clinical presentation we found strong correlation (p<0.001) which indicates lower antioxidant status in patients with severe clinical presentation. Conclusion: The results of our research showed significantly lower values of all investigated parameters in MD group related to the healthy controls, which could suggest a potential role of oxidative process in MD patophysiology.

Keywords

• Meniere disease
• oxidative stress
• antioxidant serum status