Nature Communications (Jun 2022)

Engineered non-covalent π interactions as key elements for chiral recognition

  • Ming Yu Jin,
  • Qianqian Zhen,
  • Dengmengfei Xiao,
  • Guanyu Tao,
  • Xiangyou Xing,
  • Peiyuan Yu,
  • Chen Xu

DOI
https://doi.org/10.1038/s41467-022-31026-8
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 9

Abstract

Read online

Non-covalent π interactions have been rarely used as a design element for promoting chemical reactions. Here the authors report a Sharpless asymmetric dihydroxylation (SAD)-based kinetic resolution in which a-priori-designed non-covalent forces play a central role in differentiating the enantiomeric substrates.