PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle

Staffan Hildebrand; Mohamed Ibrahim; Andreas Schlitzer; Lars Maegdefessel; Wilhelm Röll; Alexander Pfeifer

doi:10.1038/s42003-022-03140-2

Communications Biology (Mar 2022)

PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle

Staffan Hildebrand,
Mohamed Ibrahim,
Andreas Schlitzer,
Lars Maegdefessel,
Wilhelm Röll,
Alexander Pfeifer

Affiliations

Staffan Hildebrand: Institute of Pharmacology and Toxicology, University Hospital, University of Bonn
Mohamed Ibrahim: Quantitative Systems Biology, LIMES-Institute (Life and Medical Sciences Bonn), University of Bonn
Andreas Schlitzer: Quantitative Systems Biology, LIMES-Institute (Life and Medical Sciences Bonn), University of Bonn
Lars Maegdefessel: Experimental Vascular Surgery and Medicine, Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar - Technical University Munich
Wilhelm Röll: Department of Cardiac Surgery, University of Bonn
Alexander Pfeifer: Institute of Pharmacology and Toxicology, University Hospital, University of Bonn

DOI: https://doi.org/10.1038/s42003-022-03140-2
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

Read online

PDGF reduces expression of nitric oxide-sensitive soluble guanylyl cyclase (NO-sGC) through PI3K-P-Rex1-Rac1 signaling in vascular smooth muscle cells. These insights provide possible avenues to prevent dysregulation of NO/cGMP signaling in vascular disease.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal