A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions

Elena Grossi; Ivan Raimondi; Enrique Goñi; Jovanna González; Francesco P. Marchese; Vicente Chapaprieta; José I. Martín-Subero; Shuling Guo; Maite Huarte

doi:10.1038/s41467-020-14623-3

Nature Communications (Feb 2020)

A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions

Elena Grossi,
Ivan Raimondi,
Enrique Goñi,
Jovanna González,
Francesco P. Marchese,
Vicente Chapaprieta,
José I. Martín-Subero,
Shuling Guo,
Maite Huarte

Affiliations

Elena Grossi: Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of Navarra
Ivan Raimondi: Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of Navarra
Enrique Goñi: Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of Navarra
Jovanna González: Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of Navarra
Francesco P. Marchese: Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of Navarra
Vicente Chapaprieta: Departament de Fonaments Clinics, Facultat de Medicina, Universitat de Barcelona
José I. Martín-Subero: Departament de Fonaments Clinics, Facultat de Medicina, Universitat de Barcelona
Shuling Guo: Department of Antisense Drug Discovery and Clinical Development, Ionis Pharmaceuticals
Maite Huarte: Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of Navarra

DOI: https://doi.org/10.1038/s41467-020-14623-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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SWI/SNF complexes regulate chromatin architecture and gene expression. Here the authors report the RNA interactome of SMARCB1-containing SWI/SNF complexes, showing the function of SMARCB1-interacting long noncoding RNA SWINGN in transcriptional activation of GAS6 and a set of SWI/SNF target genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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