Dipeptide cholecystokinin-4 analog attenuates anxiety in "high-emotional" mice BALB/c and in ethanol-withdrawn rats: comparison with phenazepam

Abstract

Anxiolytic effects of dipeptide endogenous cholecystokinin tetrapeptide analogue GB-115 at the dose range 0,25-2,0 mg/ kg after oral administration were studied in rodents with high emotionality. In “elevated plus-maze” test GB-115 anxiolytic activity comparable with phenazepam was shown in inbred “anxious” BALB/c mice and “aged” rats with long-term 10% ethanol experience during ethanol withdrawal. GB-115 at the doses 0,5-2,0 mg/kg didn’t induce sedation, in contrast phenazepam significantly suppressed spontaneous locomotor activity in BALB/c mice in Optovarimex. The data obtained show potent anxiolytic properties GB-115 (tablet 0,001) lacking benzodiazepine’s side-effects in animal models with high emotionality.

Keywords

• гб-115
• анксиолитик
• тревожность
• алкогольная абстиненция
• мыши balb/c
• крысы
• gb-115
• anxiolytic
• anxiety
• alcohol withdrawal
• mice balb/c
• rats