Nature Communications (Jun 2022)

Probing TDP-43 condensation using an in silico designed aptamer

  • Elsa Zacco,
  • Owen Kantelberg,
  • Edoardo Milanetti,
  • Alexandros Armaos,
  • Francesco Paolo Panei,
  • Jenna Gregory,
  • Kiani Jeacock,
  • David J. Clarke,
  • Siddharthan Chandran,
  • Giancarlo Ruocco,
  • Stefano Gustincich,
  • Mathew H. Horrocks,
  • Annalisa Pastore,
  • Gian Gaetano Tartaglia

Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13


Read online

Here, the authors generated an artificial RNA molecule, or aptamer, specific for the Amyotrophic Lateral Sclerosis protein TDP-43. By interacting avidly with its target, the aptamer can be exploited to track TDP-43 phase transition in vitro and in cells.