Direct 1,3-butadiene biosynthesis in Escherichia coli via a tailored ferulic acid decarboxylase mutant

Abstract

Microorganisms cannot naturally produce 1,3-butadiene, an important monomer for synthetic rubber and plastic production, using glucose as carbon source. Here, the authors combine the cis,cis-muconic acid-production pathway and tailor ferulic acid decarboxylase mutations to achieve its production in E. coli.