International Journal of Nanomedicine (Dec 2022)
Advancement of Electrospun Nerve Conduit for Peripheral Nerve Regeneration: A Systematic Review (2016–2021)
Abstract
Shin Yee Lee,1 Soon Yong Thow,2 Shalimar Abdullah,2 Min Hwei Ng,1 Nor Hazla Mohamed Haflah2 1Centre of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur; 2Department of Orthopedics and Traumatology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala LumpurCorrespondence: Nor Hazla Mohamed Haflah, Department of Orthopedic & Traumatology’s Faculty of Medicine, UKM, Cheras, Kuala Lumpur, Tel +6012-3031316, Email [email protected]: Peripheral nerve injury (PNI) is a worldwide problem which hugely affects the quality of patients’ life. Nerve conduits are now the alternative for treatment of PNI to mimic the gold standard, autologous nerve graft. In that case, with the advantages of electrospun micro- or nano-fibers nerve conduit, the peripheral nerve growth can be escalated, in a better way. In this systematic review, we focused on 39 preclinical studies of electrospun nerve conduit, which include the in vitro and in vivo evaluation from animal peripheral nerve defect models, to provide an update on the progress of the development of electrospun nerve conduit over the last 5 years (2016– 2021). The physical characteristics, biocompatibility, functional and morphological outcomes of nerve conduits from different studies would be compared, to give a better strategy for treatment of PNI.Keywords: electrospun nerve conduit, in vivo, peripheral nerve regeneration, scaffold, animal defect model
