Nature Communications (May 2018)
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
- Sofie Voet,
- Conor Mc Guire,
- Nora Hagemeyer,
- Arne Martens,
- Anna Schroeder,
- Peter Wieghofer,
- Carmen Daems,
- Ori Staszewski,
- Lieselotte Vande Walle,
- Marta Joana Costa Jordao,
- Mozes Sze,
- Hanna-Kaisa Vikkula,
- Delphine Demeestere,
- Griet Van Imschoot,
- Charlotte L. Scott,
- Esther Hoste,
- Amanda Gonçalves,
- Martin Guilliams,
- Saskia Lippens,
- Claude Libert,
- Roos E. Vandenbroucke,
- Ki-Wook Kim,
- Steffen Jung,
- Zsuzsanna Callaerts-Vegh,
- Patrick Callaerts,
- Joris de Wit,
- Mohamed Lamkanfi,
- Marco Prinz,
- Geert van Loo
Affiliations
- Sofie Voet
- VIB Center for Inflammation Research
- Conor Mc Guire
- VIB Center for Inflammation Research
- Nora Hagemeyer
- Institute of Neuropathology, Faculty of Medicine, University of Freiburg
- Arne Martens
- VIB Center for Inflammation Research
- Anna Schroeder
- VIB Center for Brain & Disease Research
- Peter Wieghofer
- Institute of Neuropathology, Faculty of Medicine, University of Freiburg
- Carmen Daems
- Department of Human Genetics, KU Leuven
- Ori Staszewski
- Institute of Neuropathology, Faculty of Medicine, University of Freiburg
- Lieselotte Vande Walle
- VIB Center for Inflammation Research
- Marta Joana Costa Jordao
- Institute of Neuropathology, Faculty of Medicine, University of Freiburg
- Mozes Sze
- VIB Center for Inflammation Research
- Hanna-Kaisa Vikkula
- VIB Center for Inflammation Research
- Delphine Demeestere
- VIB Center for Inflammation Research
- Griet Van Imschoot
- VIB Center for Inflammation Research
- Charlotte L. Scott
- VIB Center for Inflammation Research
- Esther Hoste
- VIB Center for Inflammation Research
- Amanda Gonçalves
- VIB Center for Inflammation Research
- Martin Guilliams
- VIB Center for Inflammation Research
- Saskia Lippens
- VIB Center for Inflammation Research
- Claude Libert
- VIB Center for Inflammation Research
- Roos E. Vandenbroucke
- VIB Center for Inflammation Research
- Ki-Wook Kim
- Department of Immunology, Weizmann Institute of Science
- Steffen Jung
- Department of Immunology, Weizmann Institute of Science
- Zsuzsanna Callaerts-Vegh
- Laboratory of Biological Psychology, KU Leuven
- Patrick Callaerts
- Department of Human Genetics, KU Leuven
- Joris de Wit
- VIB Center for Brain & Disease Research
- Mohamed Lamkanfi
- VIB Center for Inflammation Research
- Marco Prinz
- Institute of Neuropathology, Faculty of Medicine, University of Freiburg
- Geert van Loo
- VIB Center for Inflammation Research
- DOI
- https://doi.org/10.1038/s41467-018-04376-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
As resident macrophages of the brain, microglia are important for neuroinflammatory responses. This work shows that nuclear factor kappa B regulatory protein A20 is important for microglia activation and regulation during inflammation of the central nervous system.
