Nutrients (Sep 2021)
Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
- Elom K. Aglago,
- Ana-Lucia Mayén,
- Viktoria Knaze,
- Heinz Freisling,
- Veronika Fedirko,
- David J. Hughes,
- Li Jiao,
- Anne Kirstine Eriksen,
- Anne Tjønneland,
- Marie-Christine Boutron-Ruault,
- Joseph A. Rothwell,
- Gianluca Severi,
- Rudolf Kaaks,
- Verena Katzke,
- Matthias B. Schulze,
- Anna Birukov,
- Domenico Palli,
- Sabina Sieri,
- Maria Santucci de Magistris,
- Rosario Tumino,
- Fulvio Ricceri,
- Bas Bueno-de-Mesquita,
- Jeroen W. G. Derksen,
- Guri Skeie,
- Inger Torhild Gram,
- Torkjel Sandanger,
- J. Ramón Quirós,
- Leila Luján-Barroso,
- Maria-Jose Sánchez,
- Pilar Amiano,
- María-Dolores Chirlaque,
- Aurelio Barricarte Gurrea,
- Ingegerd Johansson,
- Jonas Manjer,
- Aurora Perez-Cornago,
- Elisabete Weiderpass,
- Marc J. Gunter,
- Alicia K. Heath,
- Casper G. Schalkwijk,
- Mazda Jenab
Affiliations
- Elom K. Aglago
- Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC), 69372 Lyon, France
- Ana-Lucia Mayén
- Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC), 69372 Lyon, France
- Viktoria Knaze
- Early Detection, Prevention, and Infections Branch, International Agency for Research on Cancer (IARC), 69372 Lyon, France
- Heinz Freisling
- Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC), 69372 Lyon, France
- Veronika Fedirko
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
- David J. Hughes
- Cancer Biology and Therapeutics Group (CBT), Conway Institute, School of Biomolecular and Biomedical Science (SBBS), University College Dublin, D04 V1W8 Dublin, Ireland
- Li Jiao
- Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
- Anne Kirstine Eriksen
- Danish Cancer Society Research Center, 2100 Copenhagen, Denmark
- Anne Tjønneland
- Danish Cancer Society Research Center, 2100 Copenhagen, Denmark
- Marie-Christine Boutron-Ruault
- CESP, Faculté de Médecine—Université Paris-Saclay, UVSQ, INSERM, 94805 Villejuif, France
- Joseph A. Rothwell
- CESP, Faculté de Médecine—Université Paris-Saclay, UVSQ, INSERM, 94805 Villejuif, France
- Gianluca Severi
- CESP, Faculté de Médecine—Université Paris-Saclay, UVSQ, INSERM, 94805 Villejuif, France
- Rudolf Kaaks
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
- Verena Katzke
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
- Matthias B. Schulze
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany
- Anna Birukov
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany
- Domenico Palli
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), 50139 Florence, Italy
- Sabina Sieri
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, Italy
- Maria Santucci de Magistris
- Azienda Ospedaliera Universitaria Federico II, 80131 Napoli, Italy
- Rosario Tumino
- Hyblean Association for Epidemiological Research AIRE-ONLUS, 97100 Ragusa, Italy
- Fulvio Ricceri
- Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy
- Bas Bueno-de-Mesquita
- Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands
- Jeroen W. G. Derksen
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands
- Guri Skeie
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, 9037 Tromsø, Norway
- Inger Torhild Gram
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, 9037 Tromsø, Norway
- Torkjel Sandanger
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, 9037 Tromsø, Norway
- J. Ramón Quirós
- Public Health Directorate, 33402 Asturias, Spain
- Leila Luján-Barroso
- Unit of Nutrition and Cancer, Catalan Institute of Oncology—ICO; and Nutrition and Cancer Group; Epidemiology, Public Health, Cancer Prevention and Palliative Care Program, Bellvitge Biomedical Research Institute—IDIBELL, L’Hospitalet de Llobregat, Av. Granvia 199-203, 08908 Barcelona, Spain
- Maria-Jose Sánchez
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
- Pilar Amiano
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
- María-Dolores Chirlaque
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
- Aurelio Barricarte Gurrea
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
- Ingegerd Johansson
- Department of Radiation Sciences, Oncology, Umeå University, 907 36 Umeå, Sweden
- Jonas Manjer
- Department of Clinical Sciences, Malmö, Lund University, 221 00 Lund, Sweden
- Aurora Perez-Cornago
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK
- Elisabete Weiderpass
- Office of the Director, International Agency for Research on Cancer (IARC), 69372 Lyon, France
- Marc J. Gunter
- Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC), 69372 Lyon, France
- Alicia K. Heath
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK
- Casper G. Schalkwijk
- Department of Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, 6229 HX Maastrich, The Netherlands
- Mazda Jenab
- Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC), 69372 Lyon, France
- DOI
- https://doi.org/10.3390/nu13093132
- Journal volume & issue
-
Vol. 13,
no. 9
p. 3132
Abstract
Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: Nε-carboxy-methyllysine (CML), Nε-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89–1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.
Keywords