Nature Communications (Jun 2020)

Genetic drug target validation using Mendelian randomisation

  • Amand F. Schmidt,
  • Chris Finan,
  • Maria Gordillo-Marañón,
  • Folkert W. Asselbergs,
  • Daniel F. Freitag,
  • Riyaz S. Patel,
  • Benoît Tyl,
  • Sandesh Chopade,
  • Rupert Faraway,
  • Magdalena Zwierzyna,
  • Aroon D. Hingorani

DOI
https://doi.org/10.1038/s41467-020-16969-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Mendelian randomisation (MR) analysis of drug targets has potential to aid drug development. Here, the authors introduce a mathematical framework to elucidate this specific application of MR.