Nature Communications (Nov 2022)
JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm
- Rida Al-Rifai,
- Marie Vandestienne,
- Jean-Rémi Lavillegrand,
- Tristan Mirault,
- Julie Cornebise,
- Johanne Poisson,
- Ludivine Laurans,
- Bruno Esposito,
- Chloé James,
- Olivier Mansier,
- Pierre Hirsch,
- Fabrizia Favale,
- Rayan Braik,
- Camille Knosp,
- Jose Vilar,
- Giuseppe Rizzo,
- Alma Zernecke,
- Antoine-Emmanuel Saliba,
- Alain Tedgui,
- Maxime Lacroix,
- Lionel Arrive,
- Ziad Mallat,
- Soraya Taleb,
- Marc Diedisheim,
- Clément Cochain,
- Pierre-Emmanuel Rautou,
- Hafid Ait-Oufella
Affiliations
- Rida Al-Rifai
- Université Paris Cité, Inserm, PARCC, F-75015
- Marie Vandestienne
- Université Paris Cité, Inserm, PARCC, F-75015
- Jean-Rémi Lavillegrand
- Université Paris Cité, Inserm, PARCC, F-75015
- Tristan Mirault
- Université Paris Cité, Inserm, PARCC, F-75015
- Julie Cornebise
- Université Paris Cité, Inserm, PARCC, F-75015
- Johanne Poisson
- Université Paris Cité, Inserm, PARCC, F-75015
- Ludivine Laurans
- Université Paris Cité, Inserm, PARCC, F-75015
- Bruno Esposito
- Université Paris Cité, Inserm, PARCC, F-75015
- Chloé James
- Université de Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, CHU de Bordeaux, Laboratoire d’Hématologie
- Olivier Mansier
- Université de Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, CHU de Bordeaux, Laboratoire d’Hématologie
- Pierre Hirsch
- Laboratoire d’Hématologie, Hôpital Saint-Antoine, AP-HP
- Fabrizia Favale
- Laboratoire d’Hématologie, Hôpital Saint-Antoine, AP-HP
- Rayan Braik
- Université Paris Cité, Inserm, PARCC, F-75015
- Camille Knosp
- Université Paris Cité, Inserm, PARCC, F-75015
- Jose Vilar
- Université Paris Cité, Inserm, PARCC, F-75015
- Giuseppe Rizzo
- Institute of Experimental Biomedicine, University Hospital Wuerzburg
- Alma Zernecke
- Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI)
- Antoine-Emmanuel Saliba
- Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI)
- Alain Tedgui
- Université Paris Cité, Inserm, PARCC, F-75015
- Maxime Lacroix
- Service de radiologie, Hôpital Saint-Antoine, AP-HP
- Lionel Arrive
- Service de radiologie, Hôpital Saint-Antoine, AP-HP
- Ziad Mallat
- Université Paris Cité, Inserm, PARCC, F-75015
- Soraya Taleb
- Université Paris Cité, Inserm, PARCC, F-75015
- Marc Diedisheim
- GlandOmics, 41700 Cheverny, & Department of Diabetology, AP-HP, Hôpital Cochin
- Clément Cochain
- Institute of Experimental Biomedicine, University Hospital Wuerzburg
- Pierre-Emmanuel Rautou
- Université Paris Cité, Inserm, PARCC, F-75015
- Hafid Ait-Oufella
- Université Paris Cité, Inserm, PARCC, F-75015
- DOI
- https://doi.org/10.1038/s41467-022-34469-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
JAK2V617F mutation is associated with an increased risk for athero-thrombotic cardiovascular disease, but its role in aortic disease development remains unknown. Here, the authors show that JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm.
