Nature Communications (Sep 2018)
Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation
- Katharina Essig,
- Nina Kronbeck,
- Joao C. Guimaraes,
- Claudia Lohs,
- Andreas Schlundt,
- Anne Hoffmann,
- Gesine Behrens,
- Sven Brenner,
- Joanna Kowalska,
- Cristina Lopez-Rodriguez,
- Jacek Jemielity,
- Helmut Holtmann,
- Kristin Reiche,
- Jörg Hackermüller,
- Michael Sattler,
- Mihaela Zavolan,
- Vigo Heissmeyer
Affiliations
- Katharina Essig
- Institute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität München
- Nina Kronbeck
- Institute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität München
- Joao C. Guimaraes
- Computational and Systems Biology, Biozentrum, University of Basel
- Claudia Lohs
- Research Unit Molecular Immune Regulation, Helmholtz Zentrum München
- Andreas Schlundt
- Institute of Structural Biology, Helmholtz Zentrum München
- Anne Hoffmann
- Young Investigators Group Bioinformatics and Transcriptomics, Department Molecular Systems Biology, Helmholtz Centre for Environmental Research—UFZ
- Gesine Behrens
- Institute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität München
- Sven Brenner
- Research Unit Molecular Immune Regulation, Helmholtz Zentrum München
- Joanna Kowalska
- Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw
- Cristina Lopez-Rodriguez
- Immunology Unit, Department of Experimental and Health Sciences, Pompeu Fabra University
- Jacek Jemielity
- Centre of New Technologies, University of Warsaw
- Helmut Holtmann
- Institute of Biochemistry, Hannover Medical School
- Kristin Reiche
- Young Investigators Group Bioinformatics and Transcriptomics, Department Molecular Systems Biology, Helmholtz Centre for Environmental Research—UFZ
- Jörg Hackermüller
- Young Investigators Group Bioinformatics and Transcriptomics, Department Molecular Systems Biology, Helmholtz Centre for Environmental Research—UFZ
- Michael Sattler
- Institute of Structural Biology, Helmholtz Zentrum München
- Mihaela Zavolan
- Computational and Systems Biology, Biozentrum, University of Basel
- Vigo Heissmeyer
- Institute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität München
- DOI
- https://doi.org/10.1038/s41467-018-06184-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
Roquin targets are known to contain two types of sequence-structure motifs, the constitutive and the alternative decay elements (CDE and ADE). Here, the authors describe a linear Roquin binding element (LBE) also involved in target recognition, and show that Roquin binding affects the translation of a subset of targeted mRNAs.
