Deep Learning-Predicted Dihydroartemisinin Rescues Osteoporosis by Maintaining Mesenchymal Stem Cell Stemness through Activating Histone 3 Lys 9 Acetylation

• Ruoxi Wang,
• Yu Wang,
• Yuting Niu,
• Danqing He,
• Shanshan Jin,
• Zixin Li,
• Lisha Zhu,
• Liyuan Chen,
• Xiaolan Wu,
• Chengye Ding,
• Tianhao Wu,
• Xinmeng Shi,
• He Zhang,
• Chang Li,
• Xin Wang,
• Zhengwei Xie,
• Weiran Li,
• Yan Liu

Affiliations

Ruoxi Wang

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China

Yu Wang

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China

Yuting Niu

Central Laboratory, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Central Laboratory, Peking University School and Hospital for Stomatology, Beijing, China

Danqing He

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China

Shanshan Jin

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China

Zixin Li

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China

Lisha Zhu

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China

Liyuan Chen

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China

Xiaolan Wu

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China

Chengye Ding

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China

Tianhao Wu

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China

Xinmeng Shi

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China

He Zhang

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China

Chang Li

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China

Xin Wang

Peking University International Cancer Institute, Health Science Center, Peking University, Beijing, China

Zhengwei Xie

Peking University International Cancer Institute, Health Science Center, Peking University, Beijing, China

Weiran Li

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China

Yan Liu

Laboratory of Biomimetic Nanomaterials, Department of Orthodontics & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & Translational Research Center for Orocraniofacial Stem Cells and Systemic Health, Peking University School and Hospital for Stomatology, Beijing, China