Transcription Factor MYB as Therapeutic Target: Current Developments

Abstract

The MYB protein is a pivotal player in the cellular transcriptional network, influencing major important processes such as cell proliferation, differentiation, and apoptosis. Because of its role in oncogenesis, MYB is now a compelling target for therapeutic interventions in cancer research. This review summarizes its molecular functions and current therapeutic approaches aiming to inhibit its oncogenic activity.

Keywords

• MYB
• inhibitor
• AML
• leukemia
• adenoid cystic carcinoma
• transcription