Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin

Tracy Tabib; Mengqi Huang; Nina Morse; Anna Papazoglou; Rithika Behera; Minxue Jia; Melissa Bulik; Daisy E. Monier; Panayiotis V. Benos; Wei Chen; Robyn Domsic; Robert Lafyatis

doi:10.1038/s41467-021-24607-6

Nature Communications (Jul 2021)

Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin

Tracy Tabib,
Mengqi Huang,
Nina Morse,
Anna Papazoglou,
Rithika Behera,
Minxue Jia,
Melissa Bulik,
Daisy E. Monier,
Panayiotis V. Benos,
Wei Chen,
Robyn Domsic,
Robert Lafyatis

Affiliations

Tracy Tabib: Division of Rheumatology and Clinical Immunology, School of Medicine, University of Pittsburgh, Department of Medicine
Mengqi Huang: Division of Rheumatology and Clinical Immunology, School of Medicine, University of Pittsburgh, Department of Medicine
Nina Morse: Division of Rheumatology and Clinical Immunology, School of Medicine, University of Pittsburgh, Department of Medicine
Anna Papazoglou: Division of Rheumatology and Clinical Immunology, School of Medicine, University of Pittsburgh, Department of Medicine
Rithika Behera: Division of Rheumatology and Clinical Immunology, School of Medicine, University of Pittsburgh, Department of Medicine
Minxue Jia: Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh
Melissa Bulik: Division of Rheumatology and Clinical Immunology, School of Medicine, University of Pittsburgh, Department of Medicine
Daisy E. Monier: Division of Rheumatology and Clinical Immunology, School of Medicine, University of Pittsburgh, Department of Medicine
Panayiotis V. Benos: Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh
Wei Chen: Division of Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, School of Medicine, University of Pittsburgh
Robyn Domsic: Division of Rheumatology and Clinical Immunology, School of Medicine, University of Pittsburgh, Department of Medicine
Robert Lafyatis: Division of Rheumatology and Clinical Immunology, School of Medicine, University of Pittsburgh, Department of Medicine

DOI: https://doi.org/10.1038/s41467-021-24607-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Myofibroblasts drive fibrosis in systemic sclerosis (SSc), but the cellular progenitors are unknown. Utilizing single cell RNA-sequencing, the authors show that SSc dermal myofibroblasts arise in a two-step process from SFRP2/DPP4-expressing progenitors and implicate upstream transcription factors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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