Clinical, radiological and laboratory features and treatment responses of COVID-19 diseases in pregnant women

Abstract

Background: SARS-CoV-2 is more contagious than other viruses among populations. Pregnant women are particularly susceptible to respiratory pathogens and severe pneumonia. Material and Methods: Thirty-two pregnant women who were diagnosed with COVID-19 disease by PCR test in our hospital between March 2020 and June 2020 were included in this study. Patients’ complaints, comorbid disorders, general physical conditions, radiological, laboratory characteristics, treatment results, and maternal and fetus health were recorded retrospectively. Results: The mean age of the patients was 26.6 years. Pregnancy-induced hypertension was evident in 2 patients (6.2%), preeclampsia in 1 patient (3.1%), asthma in 1 patient (3.1%). Mostly detected complaints were cough (34.4%) and fatigue (31.3%). The most frequent abnormal laboratory findings were high fibrinogen level (80.9%), high D-dimer level (71.4%), high CRP level (58.1%). Lymphopenia was found in 15.6% of patients. The maternal and fetal mortality rate was 0%. The rate of improvement in laboratory values in response to the treatment was as follows respectively; sodium (92.3%), lymphocyte count (80%), LDH (62.5%), CRP (61.1%), D-dimer (25%). None of the patients developed spontaneous abortion. Cesarean delivery was performed in 15.6% of patients. 5 newborns were negative for the COVID-19 PCR test two times. Conclusions: Mostly detected complaints in pregnancy patients with COVID-19 disease were cough and fatigue. While evaluating the treatment response, the improvement in sodium level may be more valuable than the improvement in acute phase reactants. The prognosis was quite good in mothers and children treated for this disease. The vertical transition of the disease could not be demonstrated.

Keywords

• pregnant women
• clinic
• treatment
• outcome
• covid-19