An optogenetic approach for regulating human parathyroid hormone secretion

Yunhui Liu; Lu Zhang; Nan Hu; Jie Shao; Dazhi Yang; Changshun Ruan; Shishu Huang; Liping Wang; William W. Lu; Xinzhou Zhang; Fan Yang

doi:10.1038/s41467-022-28472-9

Nature Communications (Feb 2022)

An optogenetic approach for regulating human parathyroid hormone secretion

Yunhui Liu,
Lu Zhang,
Nan Hu,
Jie Shao,
Dazhi Yang,
Changshun Ruan,
Shishu Huang,
Liping Wang,
William W. Lu,
Xinzhou Zhang,
Fan Yang

Affiliations

Yunhui Liu: The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions
Lu Zhang: The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions
Nan Hu: Department of Nephrology and Shenzhen Key Laboratory of Kidney Diseases, Shenzhen People’s Hospital, The Second Clinical Medical College of Jinan University
Jie Shao: The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions
Dazhi Yang: Department of Orthopedics, Union Shenzhen Hospital, Huazhong University of Science and Technology
Changshun Ruan: Research Center for Human Tissue and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS)
Shishu Huang: Department of Orthopaedic Surgery and Orthopaedic Research Center, West China Hospital of Sichuan University
Liping Wang: The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions
William W. Lu: Department of Orthopaedics and Traumatology, The University of Hong Kong
Xinzhou Zhang: Department of Nephrology and Shenzhen Key Laboratory of Kidney Diseases, Shenzhen People’s Hospital, The Second Clinical Medical College of Jinan University
Fan Yang: The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions

DOI: https://doi.org/10.1038/s41467-022-28472-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Parathyroid hormone (PTH) plays a role in maintaining calcium and phosphorus homeostasis, and in secondary hyperparathyroidism excess PTH secretion contributes to bone loss. Here the authors report an optogenetic approach to inhibit PTH secretion in human hyperplastic parathyroid cells, and prevented hyperplastic parathyroid tissue-induced bone loss in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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