BMC Cancer (Sep 2011)

Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma

  • Liu Zhuowei,
  • Han Hui,
  • Qin Zike,
  • Jiang Zhimao,
  • Zhang Zhiling,
  • Sun Liang,
  • Wang Yong,
  • Wu Song,
  • Li Xianxin,
  • Tang Aifa,
  • Gui Yaoting,
  • Cai Zhiming,
  • Zhou Fangjian

DOI
https://doi.org/10.1186/1471-2407-11-413
Journal volume & issue
Vol. 11, no. 1
p. 413

Abstract

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Abstract Background The molecular mechanisms involved in the development and progression of clear cell renal cell carcinomas (ccRCCs) are poorly understood. The objective of this study was to analyze the expression of dual-specificity phosphatase 9 (DUSP-9) and determine its clinical significance in human ccRCCs. Methods The expression of DUSP-9 mRNA was determined in 46 paired samples of ccRCCs and adjacent normal tissues by using real-time qPCR. The expression of the DUSP-9 was determined in 211 samples of ccRCCs and 107 paired samples of adjacent normal tissues by immunohistochemical analysis. Statistical analysis was performed to define the relationship between the expression of DUSP-9 and the clinical features of ccRCC. Results The mRNA level of DUSP-9, which was determined by real-time RT-PCR, was found to be significantly lower in tumorous tissues than in the adjacent non-tumorous tissues (p Conclusion To our knowledge, this is the first study that determines the relationship between DUSP-9 expression and prognosis in ccRCC. We found that decreased expression of DUSP-9 is associated with poor prognosis in ccRCC. DUSP-9 may represent a novel and useful prognostic marker for ccRCC.