Data supporting the functional role of Eleven-nineteen Lysine-rich Leukemia 3 (ELL3) in B cell lymphoma cell line cells
Lou-Ella M.M. Alexander,
January Watters,
Jessica A. Reusch,
Michelle Maurin,
Brook S. Nepon-Sixt,
Katerina Vrzalikova,
Mark G. Alexandrow,
Paul G. Murray,
Kenneth L. Wright
Affiliations
Lou-Ella M.M. Alexander
Cancer Biology Ph.D. Program, University of South Florida, Tampa, FL 33612, United States; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa FL33612, United States
January Watters
Cancer Biology Ph.D. Program, University of South Florida, Tampa, FL 33612, United States; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa FL33612, United States
Jessica A. Reusch
Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa FL33612, United States
Michelle Maurin
Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa FL33612, United States
Brook S. Nepon-Sixt
Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL33612, United States
Katerina Vrzalikova
Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom
Mark G. Alexandrow
Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL33612, United States
Paul G. Murray
Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom
Kenneth L. Wright
Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa FL33612, United States; Correspondence to: H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, MRC-4 East, Tampa, FL 33612, United States.
The data presented here are related to the research article entitled âSelective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survivalâ (Alexander et al., 2017) [1]. The cited research article characterizes Eleven-nineteen Lysine-rich Leukemia 3 (ELL3) expression in the B cell compartment and functional dependence in B lymphoma cell lines. This data report describes the mRNA expression pattern in a panel of cell lines representing the B cell compartment, supplementing the protein expression data presented in the associated research report. In addition, a reanalysis is presented of publicly available mRNA expression data from primary murine B cells to reveal dynamic regulation of the ELL family members post LPS stimulation (Barwick et al., 2016) [2]. The effect of ELL3 depletion on cell morphology, latent Epstein Barr Virus (EBV) lytic replication and differentiation markers in a Burkitt's lymphoma (BL) cell line cells are presented. Keywords: ELL3, Transcription elongation, B-cell Lymphoma, Cell division, EBV
