Nature Communications (Jul 2016)

Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

  • Minqing Jiang,
  • Lei Liu,
  • Xuelian He,
  • Haibo Wang,
  • Wensheng Lin,
  • Huimin Wang,
  • Sung O. Yoon,
  • Teresa L. Wood,
  • Q. Richard Lu

DOI
https://doi.org/10.1038/ncomms12185
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

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The molecular mechanisms regulating myelination are only partially understood. Here authors show that Tsc1ablation in oligodendrocyte lineage activates ER stress and apoptotic programs in mice, and that enhancing PERK-eIF2α signalling partially rescues the myelination defects in Tsc1 mutants.