Nature Communications (Feb 2019)
The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins
- Kamel El Omari,
- Sai Li,
- Abhay Kotecha,
- Thomas S. Walter,
- Eduardo A. Bignon,
- Karl Harlos,
- Pentti Somerharju,
- Felix De Haas,
- Daniel K. Clare,
- Mika Molin,
- Felipe Hurtado,
- Mengqiu Li,
- Jonathan M. Grimes,
- Dennis H. Bamford,
- Nicole D. Tischler,
- Juha T. Huiskonen,
- David I. Stuart,
- Elina Roine
Affiliations
- Kamel El Omari
- Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford
- Sai Li
- Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford
- Abhay Kotecha
- Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford
- Thomas S. Walter
- Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford
- Eduardo A. Bignon
- Fundación Ciencia & Vida, Laboratorio de Virología Molecular
- Karl Harlos
- Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford
- Pentti Somerharju
- Department of Biochemistry and Developmental Biology, University of Helsinki
- Felix De Haas
- Thermo Fisher Scientific
- Daniel K. Clare
- Diamond Light Source Limited, Harwell Science and Innovation Campus
- Mika Molin
- Helsinki Institute of Life Science HiLIFE, Institute of Biotechnology, University of Helsinki
- Felipe Hurtado
- Fundación Ciencia & Vida, Laboratorio de Virología Molecular
- Mengqiu Li
- Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford
- Jonathan M. Grimes
- Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford
- Dennis H. Bamford
- Molecular and Integrative Biosciences Research Program, University of Helsinki
- Nicole D. Tischler
- Fundación Ciencia & Vida, Laboratorio de Virología Molecular
- Juha T. Huiskonen
- Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford
- David I. Stuart
- Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford
- Elina Roine
- Molecular and Integrative Biosciences Research Program, University of Helsinki
- DOI
- https://doi.org/10.1038/s41467-019-08728-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Lipid membrane fusion is an essential function in many biological processes but little is known about membrane fusion in prokaryotes. The authors here study how haloarchaeal pleomorphic viruses (HRPVs) infect archaeal hosts. The structure-function analysis of the spike proteins shed light on prokaryotic membrane fusion.
