Structural and Thermodynamic Basis of the Enhanced Interaction between Kinesin Spindle Protein Eg5 and STLC-type Inhibitors

• Hideshi Yokoyama,
• Jun-ichi Sawada,
• Kohei Sato,
• Naohisa Ogo,
• Nanami Kamei,
• Yoshinobu Ishikawa,
• Kodai Hara,
• Akira Asai,
• Hiroshi Hashimoto

Affiliations

Hideshi Yokoyama

Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan

Jun-ichi Sawada

§Center for Drug Discovery, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan

Kohei Sato

‡Department of Physical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan

Naohisa Ogo

§Center for Drug Discovery, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan

Nanami Kamei

‡Department of Physical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan

Yoshinobu Ishikawa

‡Department of Physical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan

Kodai Hara

‡Department of Physical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan

Akira Asai

§Center for Drug Discovery, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan

Hiroshi Hashimoto

‡Department of Physical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan