Molecules (Nov 2023)

New Application of <i>cyclo</i>Saligenyl Prodrugs Approach for the Delivery of Fosfoxacin Derivatives in Mycobacteria

  • Mathilde Munier,
  • Denis Tritsch,
  • Didier Lièvremont,
  • Michel Rohmer,
  • Catherine Grosdemange-Billiard

DOI
https://doi.org/10.3390/molecules28237713
Journal volume & issue
Vol. 28, no. 23
p. 7713

Abstract

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In this work, we implemented for the first time the cycloSaligenyl prodrug strategy to increase the bioavailability of fosmidomycin phosphate analogs in bacteria. Here, we report the synthesis of 34 cycloSaligenyl prodrugs of fosfoxacin and its derivatives. Among them, fifteen double prodrugs efficiently prevented the growth of the non-pathogenic, fast-growing Mycobacterium smegmatis.

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