Construction of a new luminescent Cd(ii) compound for the detection of Fe3+ and treatment of Hepatitis B

Abstract

A novel porous Cd(ii) metal–organic framework (MOF) with the chemical composition of {[H3O][Cd(bci)]}n·2n(H2O) (1, H3bci = bis(2-carboxyethyl)isocyanurate) was prepared via hydrothermal responses of H3bci and Cd(NO3)2·4H2O. Luminescent property investigations indicated that compound 1 had high sensitivity toward Fe3+, and the detection limit of Fe3+ was as low as 2.15 × 10−4 M. The application values of Fe3+ on Hepatitis B were assessed, and its associated mechanism was identified simultaneously. First, the cytotoxic mediator (TNF-α) substance released into plasma was measured through the ELISA. In addition, real-time RT-PCR was employed to determine the Hepatitis B viral replication gene relative expression levels. Finally, the novel compound’s toxicity against human normal liver cells was tested by using the CCK-8 assay.

Keywords

• cd(ii) compound
• porous framework
• luminescence sensing
• hepatitis b
• toxicity