Overuse of proton pump inhibitors and its consequences

Postępy Higieny i Medycyny Doświadczalnej. 2016;70:1112-1116 DOI 10.5604/01.3001.0009.6889

 

Journal Homepage

Journal Title: Postępy Higieny i Medycyny Doświadczalnej

ISSN: 0032-5449 (Print); 1732-2693 (Online)

Publisher: Index Copernicus International S.A.

Society/Institution: Institute of Immunology and Experimental Therapy

LCC Subject Category: Medicine

Country of publisher: Poland

Language of fulltext: English, Polish

Full-text formats available: PDF

 

AUTHORS

Marcin Kazberuk (I Klinika Nefrologii i Transplantologii z Ośrodkiem Dializ Uniwersytetu Medycznego w Białymstoku)
Szymon Brzósko (I Klinika Nefrologii i Transplantologii z Ośrodkiem Dializ Uniwersytetu Medycznego w Białymstoku)
Tomasz Hryszko (I Klinika Nefrologii i Transplantologii z Ośrodkiem Dializ Uniwersytetu Medycznego w Białymstoku)
Beata Naumnik (I Klinika Nefrologii i Transplantologii z Ośrodkiem Dializ Uniwersytetu Medycznego w Białymstoku)

EDITORIAL INFORMATION

Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 8 weeks

 

Abstract | Full Text | Full Text

Direct inhibition of H+ ion excretion to the gastric lumen makes proton pump inhibitors (PPI) the most effective drugs against gastric acid-related diseases. Over recent years usage of proton pump inhibitors has increased dramatically. Due to the low costs, high efficacy and rarity of adverse effects, their use is prevalent and often it does not correspond with existing medical guidelines. The literature lists stress ulcer prophylaxis among patients with low risk of bleeding, routine ‘gastroprotective’ medication during treatment and non-specific abdominal symptoms as the most common patterns of off-label PPI use. This article summarizes the influence of PPI therapy on gastric mucosa, absorption and occurrence of adverse effects. The authors note that their low awareness among physicians contributes to wide and imprudent use of drugs of this group.