Nature Communications (Dec 2017)
Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques
- Dawn M. Dudley,
- Christina M. Newman,
- Joseph Lalli,
- Laurel M. Stewart,
- Michelle R. Koenig,
- Andrea M. Weiler,
- Matthew R. Semler,
- Gabrielle L. Barry,
- Katie R. Zarbock,
- Mariel S. Mohns,
- Meghan E. Breitbach,
- Nancy Schultz-Darken,
- Eric Peterson,
- Wendy Newton,
- Emma L. Mohr,
- Saverio Capuano III,
- Jorge E. Osorio,
- Shelby L. O’Connor,
- David H. O’Connor,
- Thomas C. Friedrich,
- Matthew T. Aliota
Affiliations
- Dawn M. Dudley
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
- Christina M. Newman
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
- Joseph Lalli
- Department of Pathobiological Sciences, University of Wisconsin-Madison School of Veterinary Medicine, 1656 Linden Dr.
- Laurel M. Stewart
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
- Michelle R. Koenig
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
- Andrea M. Weiler
- Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Ct.
- Matthew R. Semler
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
- Gabrielle L. Barry
- Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Ct.
- Katie R. Zarbock
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
- Mariel S. Mohns
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
- Meghan E. Breitbach
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
- Nancy Schultz-Darken
- Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Ct.
- Eric Peterson
- Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Ct.
- Wendy Newton
- Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Ct.
- Emma L. Mohr
- Department of Pediatrics, University of Wisconsin-Madison, University of Wisconsin Clinical Science Center, 600 Highland Ave
- Saverio Capuano III
- Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Ct.
- Jorge E. Osorio
- Department of Pathobiological Sciences, University of Wisconsin-Madison School of Veterinary Medicine, 1656 Linden Dr.
- Shelby L. O’Connor
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
- David H. O’Connor
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
- Thomas C. Friedrich
- Department of Pathobiological Sciences, University of Wisconsin-Madison School of Veterinary Medicine, 1656 Linden Dr.
- Matthew T. Aliota
- Department of Pathobiological Sciences, University of Wisconsin-Madison School of Veterinary Medicine, 1656 Linden Dr.
- DOI
- https://doi.org/10.1038/s41467-017-02222-8
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.
