Cells (Sep 2022)

Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary Fibrosis

  • Ana Karen Torres-Soria,
  • Yair Romero,
  • Yalbi I. Balderas-Martínez,
  • Rafael Velázquez-Cruz,
  • Luz Maria Torres-Espíndola,
  • Angel Camarena,
  • Edgar Flores-Soto,
  • Héctor Solís-Chagoyán,
  • Víctor Ruiz,
  • Ángeles Carlos-Reyes,
  • Citlaltepetl Salinas-Lara,
  • Erika Rubí Luis-García,
  • Jaime Chávez,
  • Manuel Castillejos-López,
  • Arnoldo Aquino-Gálvez

DOI
https://doi.org/10.3390/cells11192938
Journal volume & issue
Vol. 11, no. 19
p. 2938

Abstract

Read online

Hypoxia and hypoxia-inducible factors (HIFs) are essential in regulating several cellular processes, such as survival, differentiation, and the cell cycle; this adaptation is orchestrated in a complex way. In this review, we focused on the impact of hypoxia in the physiopathology of idiopathic pulmonary fibrosis (IPF) related to lung development, regeneration, and repair. There is robust evidence that the responses of HIF-1α and -2α differ; HIF-1α participates mainly in the acute phase of the response to hypoxia, and HIF-2α in the chronic phase. The analysis of their structure and of different studies showed a high specificity according to the tissue and the process involved. We propose that hypoxia-inducible transcription factor 2a (HIF-2α) is part of the persistent aberrant regeneration associated with developing IPF.

Keywords