The DNA damage response pathway regulates the expression of the immune checkpoint CD47

Lucy Ghantous; Yael Volman; Ruth Hefez; Ori Wald; Esther Stern; Tomer Friehmann; Ayelet Chajut; Edwin Bremer; Michal Dranitzki Elhalel; Jacob Rachmilewitz

doi:10.1038/s42003-023-04615-6

Communications Biology (Mar 2023)

The DNA damage response pathway regulates the expression of the immune checkpoint CD47

Lucy Ghantous,
Yael Volman,
Ruth Hefez,
Ori Wald,
Esther Stern,
Tomer Friehmann,
Ayelet Chajut,
Edwin Bremer,
Michal Dranitzki Elhalel,
Jacob Rachmilewitz

Affiliations

Lucy Ghantous: Goldyne Savad Institute of Gene Therapy, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem
Yael Volman: Goldyne Savad Institute of Gene Therapy, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem
Ruth Hefez: Goldyne Savad Institute of Gene Therapy, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem
Ori Wald: Goldyne Savad Institute of Gene Therapy, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem
Esther Stern: Goldyne Savad Institute of Gene Therapy, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem
Tomer Friehmann: Goldyne Savad Institute of Gene Therapy, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem
Ayelet Chajut: Kahr Medical Ltd
Edwin Bremer: Department of Hematology, University Medical Center Groningen
Michal Dranitzki Elhalel: Department of Nephrology and Hypertension, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem
Jacob Rachmilewitz: Goldyne Savad Institute of Gene Therapy, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem

DOI: https://doi.org/10.1038/s42003-023-04615-6
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 10

Abstract

Read online

The CD47 “don’t eat me” marker is upregulated following exposure to DNA damaging agents, including irradiation, a process that is dependent on Mre11, a key player in the DNA damage response pathway.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal