Association Between Obesity and C-reactive Protein in Type 2 Diabetic Patients

Abstract

Aim: Obesity is a major health problem causing major illnesses and diseases. In this study, we aimed to differentiate type 2 diabetic normal, overweight and obese people to investigate the relationship of obesity with C-reactive protein (Hs-CRP), an inflammatory identifier. Methods: The study was conducted on a total of 129 patients (64 female, 65 male) with type 2 diabetes mellitus between May 2010 and September 2010. Study consisted of three groups, classified according to body mass; 16 normal weight, 55 overweight and 58 obese patient. Hs-CRP levels were measured by immunoassay chemiluminescence. All data were statistically analyzed. Results: A significant difference in hs-CRP levels was determined between the groups (p<0.05). Hs-CRP levels in subjects with normal body weight were found to be significantly lower than in obese ones (p<0.05). There was no significant difference in age, cholesterol parameters and HbA1c between the groups. No significant difference was observed in BMI between genders (p<0.05). Based on BMI, the rate of obese women was considerably higher than the rate of overweight and normal women (p<0.05). Similarly, the rate of overweight and normal men was significantly higher than the rate of obese men (p<0.05). Conclusion: Hs-CRP levels in people with normal body weight were confirmed to be significantly lower than those in obese people (p<0.05). Hs-CRP levels were observed to be increased with weight gain. (The Medical Bulletin of Haseki 2013; 51: 120-4)

Keywords

• Obesity
• high sensitivity C-reactive protein
• body mass index
• hemoglobin A1c protein