Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis
Merav A. Ben-David,
Benjamin W. Corn,
Ella Evron,
Hadassah Goldberg,
Raphael M. Pfeffer,
Roxoliana Abdah-Bortnyak,
Dianna Matceyevsky,
Yuliana Weinstein,
Orit Golan,
Miri Sklair-Levy
Affiliations
Merav A. Ben-David
Department of Radiation Oncology, Sheba Medical Center, Ramat-Gan, Israel; Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel
Benjamin W. Corn
Shaare Zedek Medical Center, Jerusalem, Israel; Hadassah Medical School, The Hebrew University, Jerusalem, Israel; Corresponding author. Cancer Center, Shaare Zedek Medical Center, Professor of Oncology, Tel Aviv University School of Medicine, Shaare Zedek Medical Center, 12 Shmuel Bait Street, Jerusalem, Israel.,
Ella Evron
Oncology, Kaplan Medical Institute, Rehovot, Israel; Hadassah Medical School, The Hebrew University, Jerusalem, Israel
Hadassah Goldberg
Oncology Institute, Galilee Medical Center, Naharia, Israel
Raphael M. Pfeffer
Assuta Medical Center, Tel Aviv, Israel
Roxoliana Abdah-Bortnyak
Oncology Division, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion, Haifa, Israel
Dianna Matceyevsky
Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
Yuliana Weinstein
Assuta Medical Center, Tel Aviv, Israel
Orit Golan
Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
Miri Sklair-Levy
Department of Radiation Oncology, Sheba Medical Center, Ramat-Gan, Israel; Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel
Purpose: We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer. Methods: For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density. Results: Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group. Conclusion: Reduction of BPE by PBI may contribute to its prophylactic effect.
