INTERSPHINCTERIC RESECTIONS FOR LOW RECTAL CANCER WITH ANORECTAL REGION INVOLVEMENT

Abstract

Preoperative chemoradiotherapy and surgery for low rectal cancer involving anorectal region are discussed in this article.Subjects .and .methods . 42 patients were included in this study, 18 received neoadjuvant chemoradiotherapy 5 × 5 Gy and 24 had chemo-radiotherapy up to 40 Gy in 4 Gy fractions.Results . Treatment had acceptable toxicity levels with grade III toxicity of 11.1 % and 8.3 % accordingly. 20.8 % had pathological complete response following 40 Gy chemoradiotherapy. 22.2 % patients in 5 × 5 Gy group had intershinctering resections comparing to 75 % patients in 40 Gy group. No local or distant recurrences were observed with a median followup of 42.9 months and 18.1 months accordingly.Conclusions . Developed treatment scheme have high efficacy, improving surgery ablastics and leading to good long-term outcome, improving sphincter preservation rate and patients quality of life.

Keywords

• low rectal cancer involving anorectal region
• combined treatment
• intersphincteric resections