Screening of Helicobacter pylori serum immunoglobulins in hyperemesis gravidarum

Abstract

Background Prevalence of hyperemesis gravidarum (HG) varies from 0.3 to 1.5% of all live births. The exact cause is not well known and is probably multifactorial. It is the most common cause of hospitalization in the first half of pregnancy and second only to preterm labor for pregnancy overall. The etiology of emesis gravidarum remains unknown, but a number of possible causes have been studied such as endocrinal, immunological, psychological, metabolic, genetic, and even infectious such as Helicobacter pylori infection. Objective To screen for H. pylori serum immunoglobulins in HG in pregnancy. Patients and methods This was a prospective observational cross-sectional study. The study was conducted at Abo Qir General Hospital and Al-Hussein University Hospital. The study was carried on 50 pregnant women who have vomiting sufficiently severe to produce weight loss, dehydration, acidosis from starvation, alkalosis from loss of HCL in vomitus, and hypokalemia (HG). Results Overall, 44% of cases were positive and 56% were negative regarding H. pylori immunoglobulin M. Conclusion We were unable to find an association between H. pylori and HG. We find that only 44% of cases are positive and 56% are negative regarding H. pylori immunoglobulin M, and 92% of cases had +3 ketones, and only 8% have ketones in urine from +1 to +2.

Keywords

• helicobacter pylori
• hyperemesis gravidarum
• morning sickness