Nature Communications (Feb 2022)
Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes
- Hsin-Fang Chang,
- Claudia Schirra,
- Momchil Ninov,
- Ulrike Hahn,
- Keerthana Ravichandran,
- Elmar Krause,
- Ute Becherer,
- Štefan Bálint,
- Maria Harkiolaki,
- Henning Urlaub,
- Salvatore Valitutti,
- Cosima T. Baldari,
- Michael L. Dustin,
- Reinhard Jahn,
- Jens Rettig
Affiliations
- Hsin-Fang Chang
- Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University
- Claudia Schirra
- Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University
- Momchil Ninov
- Bioanalytical Mass Spectrometry, Max Planck Institute for Multidisciplinary Sciences
- Ulrike Hahn
- Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University
- Keerthana Ravichandran
- Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University
- Elmar Krause
- Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University
- Ute Becherer
- Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University
- Štefan Bálint
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- Maria Harkiolaki
- Diamond Light Source, Harwell Science and Innovation Campus
- Henning Urlaub
- Bioanalytical Mass Spectrometry, Max Planck Institute for Multidisciplinary Sciences
- Salvatore Valitutti
- Cancer Research Center of Toulouse, INSERM U1037
- Cosima T. Baldari
- Department of Life Sciences, University of Siena
- Michael L. Dustin
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- Reinhard Jahn
- Laboratory of Neurobiology, Max Planck Institute for Multidisciplinary Sciences
- Jens Rettig
- Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University
- DOI
- https://doi.org/10.1038/s41467-022-28596-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Cytotoxic T cells have specialised granules that are important for mediating their killing function. Here the authors characterise two types of cytotoxic granules and indicate different functions and temporal release of mediators at the immunological synapse.
