Open Veterinary Journal (Feb 2024)

The impact of Apis dorsata forest honey administration on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in rats (Rattus norvegicus) forced swim test as a chronic physical animal model

  • Widjiati Widjiati,
  • Epy Muhammad Luqman,
  • Suryo Kuntjorodjakti,
  • Aulanni'am Aulanni'am,
  • Zahra Shabira,
  • Sultan Fadhilla Taqwa,
  • Riski Lesta Mega,
  • Dean Chou,
  • Ahmad Shofy Mubarak,
  • Viski Fitri Hendrawan

DOI
https://doi.org/10.5455/OVJ.2024.v14.i2.14
Journal volume & issue
Vol. 14, no. 2
pp. 738 – 742

Abstract

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Background: Chronic physical stress has many effects on the nervous system and can cause structural changes in different parts of the brain and hemomodulatory, including hormonal. Current pharmacotherapeutic treatments have limited efficacy and are associated with many deleterious side effects Aim: The aim of this research is to determine how apis dorsata forest honey administration affects FSH and LH levels in rats who are subjected to forced swim tests as a model of chronic physical stress placed in a container filled with water from which it cannot escape. Methods: This was an experimental laboratory study with 32 rats divided into four treatment groups: control (C), Treatment 1 (T1) with a forced swim test + honey (2 g/rat/day), Treatment 2 (T2) with a forced swim test + honey (4 g/rat/day), and Treatment 3 (T3) with a forced swim test + honey (6 g/rat/day). All treatments were administered for 14 days. Then blood was taken for FSH and LH serum tests, and a one-way ANOVA and Duncan test were used to statistically test the data analysis. Results: The results of this study indicate that the administration of forest honey had no significant effect (p > 0.05) on the FSH parameter, but there was a significant decrease in LH levels in the T2 and T3 groups (p [Open Vet J 2024; 14(2.000): 738-742]

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