Nature Communications (Jun 2022)

Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19

  • Mirren Charnley,
  • Saba Islam,
  • Guneet K. Bindra,
  • Jeremy Engwirda,
  • Julian Ratcliffe,
  • Jiangtao Zhou,
  • Raffaele Mezzenga,
  • Mark D. Hulett,
  • Kyunghoon Han,
  • Joshua T. Berryman,
  • Nicholas P. Reynolds

DOI
https://doi.org/10.1038/s41467-022-30932-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 11

Abstract

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Here the authors report the formation of toxic clumps of protein, similar to amyloid assemblies found in Alzheimer’s disease and suggest their possible role for some of the neurological symptoms of long-COVID.