Advances in Mechanism of LincRNA-p21 in Cancer

ZHAO Suyue; ZHU Kexiang; LI Wenjun; LI Xun

doi:10.3971/j.issn.1000-8578.2020.20.0064

Zhongliu Fangzhi Yanjiu (Oct 2020)

Advances in Mechanism of LincRNA-p21 in Cancer

ZHAO Suyue,
ZHU Kexiang,
LI Wenjun,
LI Xun

Affiliations

ZHAO Suyue: The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China
ZHU Kexiang: The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China
LI Wenjun: The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China
LI Xun: The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China

DOI: https://doi.org/10.3971/j.issn.1000-8578.2020.20.0064
Journal volume & issue: Vol. 47, no. 10
pp. 802 – 806

Abstract

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Long noncoding RNAs, which lack protein-coding capacity, regulate various biological processes through diverse molecular mechanisms. lincRNA-p21 is a tumor suppressor gene and related to p53. lincRNA-p21 regulates p53 through MDM2, ING1b, p21 and other targets, to participate in the regulation of cell cycle, proliferation and apoptosis. lincRNA-p21 coordinates the Warburg effect through HIF-1α and participates in various biological functions. lincRNA-p21 is closely related to the prognosis and treatment of tumors. Therefore, lincRNA-p21 can be used as a biomarker for cancer diagnosis and prognosis. This paper reviews the recent progress in biological function of lincRNA-p21 and its mechanism in diseases.

Published in Zhongliu Fangzhi Yanjiu

ISSN: 1000-8578 (Print)
Publisher: Magazine House of Cancer Research on Prevention and Treatment
Country of publisher: China
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.zlfzyj.com

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Abstract

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