Nature Communications (May 2020)

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

  • Ping-Chieh Pao,
  • Debasis Patnaik,
  • L. Ashley Watson,
  • Fan Gao,
  • Ling Pan,
  • Jun Wang,
  • Chinnakkaruppan Adaikkan,
  • Jay Penney,
  • Hugh P. Cam,
  • Wen-Chin Huang,
  • Lorena Pantano,
  • Audrey Lee,
  • Alexi Nott,
  • Trongha X. Phan,
  • Elizabeta Gjoneska,
  • Sara Elmsaouri,
  • Stephen J. Haggarty,
  • Li-Huei Tsai

DOI
https://doi.org/10.1038/s41467-020-16361-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Defects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseases.