Nature Communications (May 2020)
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
- Ping-Chieh Pao,
- Debasis Patnaik,
- L. Ashley Watson,
- Fan Gao,
- Ling Pan,
- Jun Wang,
- Chinnakkaruppan Adaikkan,
- Jay Penney,
- Hugh P. Cam,
- Wen-Chin Huang,
- Lorena Pantano,
- Audrey Lee,
- Alexi Nott,
- Trongha X. Phan,
- Elizabeta Gjoneska,
- Sara Elmsaouri,
- Stephen J. Haggarty,
- Li-Huei Tsai
Affiliations
- Ping-Chieh Pao
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Debasis Patnaik
- Chemical Neurobiology Laboratory, Departments of Neurology and Psychiatry, Massachusetts General Hospital and Harvard Medical School
- L. Ashley Watson
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Fan Gao
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Ling Pan
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Jun Wang
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Chinnakkaruppan Adaikkan
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Jay Penney
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Hugh P. Cam
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Wen-Chin Huang
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Lorena Pantano
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Audrey Lee
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Alexi Nott
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Trongha X. Phan
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Elizabeta Gjoneska
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Sara Elmsaouri
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- Stephen J. Haggarty
- Chemical Neurobiology Laboratory, Departments of Neurology and Psychiatry, Massachusetts General Hospital and Harvard Medical School
- Li-Huei Tsai
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology
- DOI
- https://doi.org/10.1038/s41467-020-16361-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Defects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseases.
