Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue

Masahide Kawatou; Hidetoshi Masumoto; Hiroyuki Fukushima; Gaku Morinaga; Ryuzo Sakata; Takashi Ashihara; Jun K. Yamashita

doi:10.1038/s41467-017-01125-y

Nature Communications (Oct 2017)

Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue

Masahide Kawatou,
Hidetoshi Masumoto,
Hiroyuki Fukushima,
Gaku Morinaga,
Ryuzo Sakata,
Takashi Ashihara,
Jun K. Yamashita

Affiliations

Masahide Kawatou: Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University
Hidetoshi Masumoto: Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University
Hiroyuki Fukushima: Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University
Gaku Morinaga: Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University
Ryuzo Sakata: Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine
Takashi Ashihara: Department of Cardiovascular Medicine, Shiga University of Medical Science
Jun K. Yamashita: Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University

DOI: https://doi.org/10.1038/s41467-017-01125-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Torsade de Pointes (TdP) is a life-threatening ventricular arrhythmia often caused by drugs. In response to an urgent need for human tissue TdP models, here the authors describe a 3D human iPS cell-engineered heart tissue that generates TdP in response to drugs, providing a suitable model for studies of TdP mechanism and drug toxicity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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