Nature Communications (Feb 2021)

Eltrombopag directly inhibits BAX and prevents cell death

  • Adam Z. Spitz,
  • Emmanouil Zacharioudakis,
  • Denis E. Reyna,
  • Thomas P. Garner,
  • Evripidis Gavathiotis

DOI
https://doi.org/10.1038/s41467-021-21224-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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The BCL-2 family protein BAX functions to regulate mitochondria-driven cell death. Here the authors show that the drug Eltrombopag inhibits BAX and prevents apoptosis induced by cytotoxic stimuli.