Nature Communications (Mar 2023)
Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis
- Yasuaki Uehara,
- Yusuke Tanaka,
- Shuyang Zhao,
- Nikolaos M. Nikolaidis,
- Lori B. Pitstick,
- Huixing Wu,
- Jane J. Yu,
- Erik Zhang,
- Yoshihiro Hasegawa,
- John G. Noel,
- Jason C. Gardner,
- Elizabeth J. Kopras,
- Wendy D. Haffey,
- Kenneth D. Greis,
- Jinbang Guo,
- Jason C. Woods,
- Kathryn A. Wikenheiser-Brokamp,
- Jennifer E. Kyle,
- Charles Ansong,
- Steven L. Teitelbaum,
- Yoshikazu Inoue,
- Göksel Altinişik,
- Yan Xu,
- Francis X. McCormack
Affiliations
- Yasuaki Uehara
- Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine
- Yusuke Tanaka
- Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine
- Shuyang Zhao
- Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center
- Nikolaos M. Nikolaidis
- Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine
- Lori B. Pitstick
- Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine
- Huixing Wu
- Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine
- Jane J. Yu
- Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine
- Erik Zhang
- Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine
- Yoshihiro Hasegawa
- Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine
- John G. Noel
- Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine
- Jason C. Gardner
- Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine
- Elizabeth J. Kopras
- Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine
- Wendy D. Haffey
- Department of Cancer Biology, University of Cincinnati College of Medicine
- Kenneth D. Greis
- Department of Cancer Biology, University of Cincinnati College of Medicine
- Jinbang Guo
- Center for Pulmonary Imaging Research, Cincinnati Children’s Hospital Medical Center
- Jason C. Woods
- Center for Pulmonary Imaging Research, Cincinnati Children’s Hospital Medical Center
- Kathryn A. Wikenheiser-Brokamp
- Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center
- Jennifer E. Kyle
- Biological Sciences Division, Pacific Northwest National Laboratory
- Charles Ansong
- Biological Sciences Division, Pacific Northwest National Laboratory
- Steven L. Teitelbaum
- Department of Pathology, Washington University School of Medicine
- Yoshikazu Inoue
- Department of Diffuse Lung Diseases and Respiratory Failure, Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center
- Göksel Altinişik
- Department of Chest Diseases, Faculty of Medicine, Pamukkale University
- Yan Xu
- Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center
- Francis X. McCormack
- Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-36810-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 17
Abstract
Osteoclasts are derived from circulating myeloid cells to mediate bone repair, maintenance and remodeling. Here, the authors show that the lung also recruits and reprograms monocytes and alveolar macrophages into osteoclast-like cells to clear pathogenic particles from the airspace.
