Ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis

Sallagundla Bhavani; Dandela Rambabu; Mandava Venkata Basaveswara Rao; Manojit Pal

Arabian Journal of Chemistry (Dec 2019)

Ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis

Sallagundla Bhavani,
Dandela Rambabu,
Mandava Venkata Basaveswara Rao,
Manojit Pal

Affiliations

Sallagundla Bhavani: Department of Chemistry, K. L. University, Vaddeswaram, Guntur 522502, Andhra Pradesh, India
Dandela Rambabu: Department of Chemistry and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be’er-Sheva 84105, Israel
Mandava Venkata Basaveswara Rao: Department of Chemistry, Krishna University, Machilipatnam 521001, Andhra Pradesh, India; Corresponding authors. Tel.: +91 40 6657 1500.
Manojit Pal: Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, India; Corresponding authors. Tel.: +91 40 6657 1500.

Journal volume & issue: Vol. 12, no. 8
pp. 4189 – 4196

Abstract

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A convenient synthetic method has been developed for accessing 2,6-dialkynyl-3,5-dichloropyridine derivatives in acceptable to good yields. The methodology involved ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis. A variety of terminal alkynes were employed in this CC coupling reaction to afford the corresponding 2,6-dialkynyl-3,5-dichloropyridine derivatives. Keywords: Pyridine, Alkynes, Pd/C, Ultrasound

Published in Arabian Journal of Chemistry

ISSN: 1878-5352 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/arabian-journal-of-chemistry/

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